Intestinal Dysbiosis in Patients with Histamine Intolerance
New study published about microbiota, histamine intolerance and DAO deficiency by the research team of the University of Barcelona (Dr. Mª Carmen Vidal). Adding clinical and scientific evidence every day.
Download the scientific paper through here
Abstract: An underlying cause of histamine intolerance is diamine oxidase (DAO) deficiency, which leads to defective homeostasis and a higher systemic absorption of histamine. Impaired DAO activity may have a genetic, pharmacological or pathological origin. A recent proposal also suggests it can arise from an alteration in the gut microbiota, although only one study has explored this hypothesis to date. A greater abundance of histamine-secreting bacteria in the gut could lead to the development of histamine ntolerance. Thus, the aim of this study was to characterize the composition of the intestinal microbiota of patients with histamine intolerance symptoms and compare it with that of healthy individuals. The study was performed by sequencing bacterial 16S rRNA genes (V3-V4 region) and analyzing the data using the EzBioCloud Database. Dysbiosis of the gut microbiota was observed in the histamine intolerance group who, in comparison with the healthy individuals, had a significantly lower proportion of Prevotellaceae, Ruminococcus, Faecalibacterium and Faecablibacterium prausnitzii, which are bacteria related to gut health. They also had a significantly higher abundance of histaminesecreting bacteria, including the genera Staphylococcus and Proteus, several unidentified genera belonging to the family Enterobacteriaceae and the species Clostridium perfringens and Enterococcus faecalis. A greater abundance of histaminogenic bacteria would favor the accumulation of high levels of histamine in the gut, its subsequent absorption in plasma and the appearance of adverse effects, even in individuals without DAO deficiency.
Sònia Sánchez-Pérez 1,2,3 , Oriol Comas-Basté 1,2,3 , Adriana Duelo 1,2,3, M. Teresa Veciana-Nogués 1,2,3 ,
Mercedes Berlanga 4 , M. Luz Latorre-Moratalla 1,2,3,† and M. Carmen Vidal-Carou 1,2,3,*,†
1 Department de Nutrició, Ciències de l’Alimentació i Gastronomía, Facultat de Farmàcia i Ciències de l’Alimentació, Campus de l’Alimentació de Torribera, Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain; soniasanchezperez@ub.edu (S.S.-P.); oriolcomas@ub.edu (O.C.-B.); aduelo@ub.edu (A.D.); veciana@ub.edu (M.T.V.-N.); mariluzlatorre@ub.edu (M.L.L.-M.)
2 Institut de Recerca en Nutrició i Seguretat Alimentària (INSAUB), Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain
3 Xarxa d’Innovació Alimentària (XIA), C/Baldiri Reixac 4, 08028 Barcelona, Spain
4 Departament de Biologia, Sanitat i Mediambient, Secció de Microbiologia, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona (UB), Av. Joan XXIII 27-31, 08028 Barcelona, Spain; mberlanga@ub.edu
- Correspondence: mcvidal@ub.edu
† These authors contributed equally to this work.
Citation: Sánchez-Pérez, S.; Comas-Basté, O.; Duelo, A.; Veciana-Nogués, M.T.; Berlanga, M.; Latorre-Moratalla, M.L.; Vidal-Carou, M.C. Intestinal Dysbiosis in Patients with Histamine Intolerance. Nutrients 2022, 14, 1774. https://doi.org/10.3390/nu14091774
Migraine, itching, stomach pain… This is how DAO deficiency affects you – SABER VIVIR tve
On October 23rd the magazine SABER VIVIR tve published an article about the DAO deficiency, its causes and management called “Migraine, itching, stomach pain… This is how DAO deficiency affects you”.
It is signed by the journalist specialized in health Eva Mimbrero and has the advice of the allergist Dr. Pedro Ojeda, co-director of the clinic Ojeda of Asthma and Allergy and a member of the International Society of Deficit of DAO.
To access the original article click here clic here.
What is histamine?
The article begins by explaining what the histamine molecule is, what its sources are in the organism (since it is produced and stored in certain cells, and can also be acquired through food in the case of a deficit of DAO) and what physiological functions it performs, among which are the secretion of gastric juices, processes of the immune system, neurotransmission in the nervous system, among others.
Which systems are affected?
After introducing the role of histamine in the body, the deficit of DAO and its symptoms are discussed. This consists of an alteration in the metabolism of histamine that comes from food, this alteration being caused by the deficit of the enzyme Diamino Oxidase.
Among its symptoms at the neurological level is migraine (87% of people who suffer from migraine have a deficit of DAO, according to a clinical study conducted in Spain), at the skin level itching, redness, emergence of beans, hives and angioedema, at intestinal level gastric pain, cramps, gas or diarrhea, at gynecological level menstrual pain, at cardiac level palpitations, arrhythmias or tachycardias, and at respiratory level rhinitis and the feeling that it is difficult to breathe.
Which are the causes?
Before going on to talk about methods for the dietary management of the symptoms of DAO deficiency, it is emphasized that DAO deficiency is not an allergic response but that its effects and control are more prolonged over time, being more durable and less instantaneous processes.
Finally, the article identifies the main causes of DAO deficiency, among which are the genetic alteration in the individual’s DAO enzyme, certain inflammatory intestinal disorders that alter the intestinal mucosa where DAO is produced (such as celiac disease, Crohn’s disease or ulcerative colitis), the consumption of certain drugs that inhibit the enzyme, or the consumption of alcoholic beverages, since alcohol also acts as a potent inhibitor of the enzyme.
How to handle it?
Once these causes have been identified, it ends up talking about the management of the symptoms, in which its three fundamental pillars are the diagnosis of the specific cause in each patient, avoiding the consumption of alcohol and certain foods rich in histamine, as well as keeping a medical control of the drugs that are consumed, and finally following a dietary supplementation of diamond oxidase.
To access the original article click here clic here.