Activate your DAO and forget the discomfort

DAOfood® Plus: Dietary management of histamine symptoms caused by DAO Deficiency


Dietary management of DAO deficiency.

49.95$ (VAT included)

 Highly active and bioavailable Diamine Oxidase (DAO) enzyme. Ideal for prolonged dietary management of DAO deficiency.

  It includes Quercetin and Vitamin C as adjuvant ingredients that work in synergy with the DAO enzyme.

  With the innovative Eficaps® technology based on capsules with gastroresistant tablets that allow the release of the ingredients at the required time and place of action.

   DAO intake through DAOfood Plus helps to increase the breakdown of exogenous or dietary histamine in the gut.


DAOfood®Plus is a dietary supplement for the dietary management of DAO Deficiency.

DAOfood®Plus supports digestive health by breaking down histamine and supporting normal DAO levels.

The amount of DAO contained in DAOfood Plus complements the body’s own enzyme, enhancing the breakdown of dietary histamine. Thus, DAOfood Plus supports histamine metabolism locally in the small intestine and, in combination with quercetin and vitamin C as adjuvants, restores the natural balance of histamine and DAO.

Histamine is an essential molecule, a transmitter that belongs to the so-called group of biogenic amines and that is naturally present in many foods as well as inside our cells. Normally, the intake of histamine contained in food does not cause any problem, since it is quickly processed and metabolized by the Diamine Oxidase enzyme (DAO).

DAO is the main enzyme for the metabolism of ingested histamine. lt is mainly located in the intestinal epithelium, where it absorbs and degrades the ingested histamine preventing it from passing into the bloodstream.

When there is an imbalance between the ingested histamine and the enzyme capacity or activity to metabolize it, histamine passes into the bloodstream which can trigger different reactions. Some causes of lower DAO Deficiency include:

  1. GENETIC ORIGIN: identified polymorphism.
    • Pathological: Gastrointestinal conditions.
    • Pharmacological: Certain drugs blocking DAO enzyme.
    • Alcoholic Drinks and certain drugs may reduce or block DAO enzymatic activity: ethanol is a DAO enzyme blocker.

Histamine is present in all foods a greater or lesser extent, whether plant or animal origin. Food undergoing a lengthy maturation or food stored for an extended period is particularly high in histamine and other biogenic amines also degraded by DAO enzyme.

These foods are, among others:

  • Raw or pasteurized milk and dairy products.
  • Citrus fruits, strawberries, and banana.
  • Seafood, oily fish, and fish sauces.
  • Raw cured sausage such as spiced sausage and bacon.
  • Some vegetables such as tomatoes, spinach, or eggplant
  • Alcoholic drinks*, especially red and sparkling wine.

*Alcoholic drinks contain, to some extent, histamine, or other biogenic amines, and furthermore, alcohol inhibits DAO activity impeding histamine degradation and metabolization.

What does DAOfood®Plus contain?

Eficaps® capsules of DAOfood®Plus contain gastro-resistant tablets with controlled release DAO in the intestine that prevent stomach acid pH and tablets that guarantee the immediate release of adjuvant active ingredients.

Each capsule contains four tablets:

  2 DAO white/beige gastro-resistant tablets with release into the intestine.

  1 orange tablet for immediate release with vitamin C.

 1 yellow tablet for immediate release with quercetin*.

(*) If you cannot take quercetin, you can open the capsule and remove the yellow tablet.

How should DAOfood®Plus be used?

Take 1 capsule with some water 20 minutes before the main meals (3 times a day). The capsule should be swallowed whole, if you are unable to swallow it whole, please open it and ingest the tablets from its interior separately, swallowing them whole without chewing, splitting or breaking them.

lmportant observations

Alcohol and medicines may largely inhibit the action of the Diamine Oxidase enzyme (DAO). Store in a cool place. The capsules must be swallowed whole. It does not contain Histamine. Gluten free. Lactose free.


DAOfood®Plus contains Diamine Oxidase (DAO), a thermolabile enzyme (sensitive to temperature) that should be stored away from heat sources. No special preservation precautions are required if daily intake guidelines are followed. In the case of occasional use, the product should be kept refrigerated.

Bulking agents: microcrystalline cellulose and hydroxypropylcellulose; quercetin 95%; potato starch; L-ascorbic acid (vitamin C); coating agent: ethylcellulose; pig kidney protein extract with 7% diamine oxidase (DAO); bulking agent: hydroxypropyl methylcellulose; stabilizers: magnesium salts of fatty acids, sodium alginate; rice starch, medium chain triglycerides; stabilizer: stearic acid, oleic acid, dicalcium phosphate; coloring agent: caramel E150d. Vegetable capsule: hydroxypropyl methylcellulose.


Histamine is a molecule that is present in all foods in the daily diet, is also produced endogenously in the body, and is the mediator of many biological processes such as hypersensitivity or the body’s defense reactions gastric acid secretions, neuromodulation and regulation of immune function. Ingested histamine is broken down by the enzyme Diamine Oxidase (DAO) in the small intestine.

The Issue

If the metabolic activity of the DAO enzyme is reduced, the ingested histamine cannot be degraded and passes through the intestinal mucosa to the bloodstream.

The solution

DAOfood® Plus provides the exogenous DAO intake necessary to restore histamine metabolism. Proper DAO supplementation allows dietary management of DAO levels.

Legal Disclaimer

These statements have not been evaluated by the FDA.  This product is not intended to diagnose, treat, cure, or prevent any disease or health condition.


Migraine and headaches.

Digestive disorders such as bloated feeling, flatulence, constipation or diarrhoea.

Pain and muscle contractures and osteopathic pain.

Skin disorders, such as dry or atopic skin.

The enzyme Diamine Oxidase (DAO) from DAOfood® Plus maintains its metabolic activity of food histamine for 4-5 hours after taking the supplement.

The normal recommended dose is one capsule (or tablet) before each meal. Up to 3 capsules or tablets can be taken before meals rich in histamine.

Taking DAO for at least 15 days can help to support normal DAO levels. Normalization of DAO levels result in normalization of the biological processes associated with the intake of histamine rich products from the diet.

It is recommended to follow a low histamine diet and take one capsule at least 3 times a day (take one capsule before each main meal).

DAOfood® Plus can be taken indefinitely, being suitable for diabetics, celiacs and / or people with food intolerance, it does not contain allergens, gluten, lactose or histamine, and it does not cause side effects.

Each dose of DAOfood® Plus contains 4.2 mg of pig kidney protein extract rich in DAO enzyme with an enzymatic activity of 0.41 mU/20,000 HDU per dose.

Each capsule contains 40 mg of quercetin inside in a yellow tablet. Quercetin is a known flavonoid with antihistamine activity. Its immediate release acts in synergy with the DAO enzyme in the metabolism of dietary histamine.

Each capsule contains 20 mg of vitamin C in an orange tablet. Vitamin C increases the metabolic activity of the enzyme DAO and quercetin.

Each capsule can be opened, and tablets not required can be removed as appropriate. The withdrawal of quercetin tablets, yellow in color, and / or vitamin C, orange in color, do not compromise the effectiveness of the product.

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