Activate your DAO and forget the discomfort

DAOfood® Plus: Dietary management of histamine symptoms caused by DAO Deficiency


Dietary management of DAO deficiency.

49.95$ (VAT included)

 Highly active and bioavailable Diamine Oxidase (DAO) enzyme. Ideal for prolonged dietary management of DAO deficiency and its non-allergic symptoms.

  It includes Quercetin and Vitamin C as adjuvant ingredients that work in synergy with the DAO enzyme.

  With the innovative Eficaps® technology based on capsules with gastroresistant tablets that allow the release of the ingredients at the required time and place of action.

   DAO intake through DAOfood Plus helps to increase the breakdown of exogenous or dietary histamine in the intestine thus reducing its systemic absorption


DAOfood®Plus is a dietary supplement for the dietary management of DAO Deficiency.

DAOfood®Plus supports digestive health by breaking down histamine and reducing histamine intolerance reactions caused by DAO Deficiency.

The amount of DAO contained in DAOfood®Plus boosts the body’s own enzyme, enhancing the breakdown of dietary histamine. Thus, DAOfood®Plus supports histamine metabolism locally in the small intestine and, in combination with quercetin and vitamin C as adjuvants, restores the natural balance of histamine and DAO.

Histamine is an essential molecule, a transmitter that belongs to the so called group of biogenic amines and that is naturally present in many foods as well as inside our cells. Normally, the intake of histamine contained in food does not cause any problem, since it is quickly processed and metabolized by the Diamine Oxidase enzyme (DAO).

DAO is the main enzyme for the metabolism of ingested histamine. lt is mainly located in the intestinal epithelium, where it absorbs and degrades the ingested histamine preventing it from passing into the bloodstream.

lt refers to a deficiency in Diamine Oxidase (DAO) metabolization activity or when there is an imbalance between the ingested histamine and the enzyme capacity to metabolize it. As histamine has not been properly metabolized and degraded, it passes into the bloodstream triggering different manifestations. The causes of DAO Deficiency are:


Identified polymorphisms.


Gatrointestinal conditions such as: Inflammatory bowel diseases.

Alcoholic drinks and certain drugs may reduce or block DAO enzymatic activity.

Histamine is present in all foods a greater or lesser extent, whether plant or animal origin. Food undergoing a lengthy maturation or food stored for an extended period is particularly high in histamine and other biogenic amines also degraded by DAO enzyme.

These foods are, among others:

  • Raw or pasteurized milk and dairy products.
  • Citrus fruits, strawberries and banana.
  • Seafood, oily fish and fish sauces.
  • Raw cured sausage such as spiced sausage, chorizo or bacon.
  • Some vegetables such as tomatoes, spinach or aubergines.
  • Alcoholic drinks*, especially red and sparkling wine.

*Alcoholic drinks contain, to some extent, histamine or other biogenic amines, and furthermore, alcohol inhibits DAO activity impeding histamine degradation and metabolization.

What does DAOfood®Plus contain?

Eficaps® capsules of DAOfood®Plus contain gastro-resistant tablets with controlled release DAO in the intestine that prevent stomach acid pH and tablets that guarantee the immediate release of adjuvant active ingredients.

Each capsule contains four tablets:

  2 DAO white/beige gastro-resistant tablets with release into the intestine.

  1 orange tablet for immediate release with vitamin C.

 1 yellow tablet for immediate release with quercetin*.

(*) If you can not take quercetine, you can open the capsule and remove the yellow tablet.

How should DAOfood®Plus be used?

Take 1 capsule with some water 20 minutes before the main meals (3 times a day). The capsule should be swallowed whole, if you are unable to swallow it whole, please open it and ingest the tablets from its interior separately, swallowing them whole without chewing, splitting or breaking them.

lmportant observations

Alcohol and medicines may largely inhibit the action of the Diamine Oxidase enzyme (DAO). Please ask for professional advice in case of doubt about how to use this supplement. Keep out of the reach of children. Store in a cool place. The capsules must be swallowed whole. It does not contain Histamine. Gluten free and lactose free as per the regulations 21CFR168.122.


DAOfood®Plus contains Diamine Oxidase (DAO), a thermolabile enzyme (sensitive to temperature), and as such it is advisable to keep it away from heat sources. If consumed according to the recommended daily dose, it does not require any special storage conditions, but if as an exception it is consumed only sporadically and is thus stored for extended time periods, it is advisable to store it in a refrigerator.

Bulking agents: microcrystalline cellulose and hydroxypropylcellulose; quercetin 95%; potato starch; L-ascorbic acid (vitamin C); coating agent: ethylcellulose; pig kidney protein extract with 7% diamine oxidase (DAO); bulking agent: hydroxypropyl methylcellulose; stabilizers: magnesium salts of fatty acids, sodium alginate; rice starch, medium chain triglycerides; stabilizer: stearic acid, oleic acid, dicalcium phosphate; coloring agent: caramel E150d. Vegetable capsule: hydroxypropyl methylcellulose.


Histamine is a molecule that is present in all foods in the daily diet, is also produced endogenously in the body, and is the mediator of many biological processes such as hypersensitivity or body’s defense reactions, gastric acid secretions, neuromodulation and regulation of immune function.

In people who has not DAO deficiency, ingested histamine is broken down by the enzyme Diamine Oxidase (DAO) in the small intestine.

The problem

If the metabolic activity of the DAO enzyme is reduced (due to genetic, pharmacological and / or pathological factors), the ingested histamine cannot be degraded and passes through the intestinal mucosa to the circulation causing the appearance of histamine intolerance symptoms.

The solution

DAOfood®Plus provides the exogenous DAO intake necessary to restore histamine metabolism. Proper DAO supplementation allows dietary management of your symptoms.

These statements have not been evaluated by the FDA.  This product is not intended to diagnose, treat, cure, or prevent any disease or health condition.


  • Migraine and headaches.
  • Digestive disorders such as bloated feeling, flatulence,  constipation or diarrhoea.
  • Pain and muscle contractures and osteophatic pain.
  • Skin disorders, such as dry or atopic skin.

The enzyme Diamine Oxidase (DAO) from DAOfood® Plus maintains its metabolic activity of food histamine for 4-5 hours after taking the supplement.

It can be consumed before a meal up to a maximum of 3 capsules, being advisable not to consume more than 3 capsules daily. In this way, if for having a meal rich in histamine in a day 2 or 3 capsules are consumed before it, it is advisable that if 2 capsules have been consumed, only one more capsule is consumed at the next meal during that day, and If 3 capsules have been consumed, do not consume any more capsules during that day.

The results of the dietary treatment (reduction of the duration and intensity of the symptoms, increase of the period between episodes and improvement of the symptoms produced by Histamine Intolerance caused by DAO deficiency) begin to be appreciated 15 days after the supplementation and within the first 30 days. 

It is recommended to follow a low histamine diet and take one capsule at least 3 times a day (take one capsule before each main meal).

DAOfood® Plus can be taken indefinitely, being suitable for diabetics, celiacs and / or people with food intolerance, it does not contain allergens, gluten, lactose or histamine, and it does not cause side effects, which is why it is suitable for the dietary management of different symthoms associated with Histamine Intolerance caused by DAO deficiency.

Each dose of DAOfood Plus contains 4.2 mg of pig kidney protein extract rich in DAO enzyme with an enzymatic activity of 0.41 mU/20,000 HDU per dose.

Each capsule contains 40 mg of quercetin inside in a yellow tablet. Quercetin is a known flavonoid with antihistamine activity. Its immediate release acts in synergy with the DAO enzyme in the metabolism of dietary histamine.

Each capsule contains 20 mg of vitamin C in an orange tablet. Vitamin C increases the metabolic activity of the enzyme DAO and quercetin.

Each capsule can be opened and removed those tablets that, are not necessary for the dietary management of your histamine reactions The withdrawal of quercetin tablets, yellow in color, and / or vitamin C, orange in color, do not compromise the effectiveness of dietary management, being adjuvant ingredients used to adapt to the nutritional requirements of each patient.

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