Biomolecules 2022, 12, 454. https://doi.org/10.3390/biom12030454
Ying Zhao 1,2,† , Xiaoyan Zhang 1,2,† , Hengxi Jin 2 , Lu Chen 1,2, Jiang Ji 1,2,* and Zhongwei Zhang 3,*
1 Department of Dermatology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China;
nanjjzhaoying@126.com (Y.Z.); hiohikari@163.com (X.Z.); chenlu1275@163.com (L.C.)
2 Department of Dermatology and Venereology, Suzhou Medical College of Soochow University,
Suzhou 215000, China; jinhengxi1995@163.com
3 Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University,
Nantong 226001, China
*Correspondence: jijiang@suda.edu.cn (J.J.); zhangzwei22@gmail.com (Z.Z.); Tel.: +86-0512-6778-3484 (J.J.)
† These authors contributed equally to this work.
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Abstract:
Histamine intolerance (HIT) is a common disorder associated with impaired histamine metabolism. Notwithstanding, it is often misdiagnosed as other diseases because of its lack of specific clinical manifestations. HIT did not gain traction until the early 21st century. In this review, we will focus on the latest research and elaborate on the clinical manifestations of HIT, including its manifestations in special populations such as atopic dermatitis (AD) and chronic urticaria (CU), as well as the latest understanding of its etiology and pathogenesis. In addition, we will explore the latest treatment strategies for HIT and the treatment of specific cases.
